Quantum-Inspired Optimization for High-Dimensional Data Classification in Healthcare Analytics

Authors

  • Hanae Sugimoto 2Keio University, Tokyo, Japan
  • Kaito Morishita 2Keio University, Tokyo, Japan

DOI:

https://doi.org/10.51903/jtie.v4i3.451

Keywords:

Quantum-Inspired Optimization, Variational Quantum Algorithms, High-Dimensional Data Classification, Healthcare Analytics, Computational Efficiency in Artificial Intelligence

Abstract

High-dimensional medical datasets pose a persistent challenge for artificial intelligence because traditional classification algorithms often incur escalating computational costs and reduced predictive accuracy. As healthcare systems generate increasingly complex clinical records, imaging outputs, and genomic profiles, scalable analytic methods that balance precision and efficiency are critical. This study proposes a Quantum-Inspired Optimization (QIO) framework for efficient and accurate classification of high-dimensional healthcare data. Leveraging the exploratory power of variational quantum algorithms, specifically techniques analogous to the Quantum Approximate Optimization Algorithm, the framework integrates quantum-style search strategies with classical computation to achieve global optimization and numerical stability. Publicly available medical datasets with hundreds of features were used to evaluate the approach. Classification models were trained and tested across varying feature dimensionalities, and performance was assessed using accuracy, runtime, and scalability metrics. Empirical results demonstrate that QIO achieves up to 95.4% classification accuracy and reduces computational time by 40% compared with state-of-the-art classical baselines. The method demonstrates stable convergence and clear decision boundaries even as feature dimensionality grows, highlighting its resilience to the curse of dimensionality. These results indicate that QIO can enable fast and reliable healthcare analytics in data-rich clinical environments. Future research may examine domain-specific adaptations, real-time deployment, and integration with emerging quantum hardware to enhance the impact of quantum-inspired artificial intelligence further.

References

Ahmad, T., Zhang, D., Huang, C., Zhang, H., Dai, N., Song, Y., & Chen, H. (2021). Artificial Intelligence in Sustainable Energy Industry: Status Quo, Challenges and Opportunities.

Ahmed, A., Xi, R., Hou, M., Shah, S. A., & Hameed, S. (2023). Harnessing Big Data Analytics for Healthcare: A Comprehensive Review of Frameworks, Implications, Applications, and Impacts. IEEE Access, 11, 112891–112928. https://doi.org/10.1109/ACCESS.2023.3323574

Amaro, D., Modica, C., Rosenkranz, M., Fiorentini, M., Benedetti, M., & Lubasch, M. (2022). Filtering variational quantum algorithms for combinatorial optimization. Quantum Science and Technology, 7(1). https://doi.org/10.1088/2058-9565/ac3e54

Angelis, D., Sofos, F., & Karakasidis, T. E. (2023). Artificial Intelligence in Physical Sciences: Symbolic Regression Trends and Perspectives. In Archives of Computational Methods in Engineering (Vol. 30, Issue 6, pp. 3845–3865). Springer Science and Business Media B.V. https://doi.org/10.1007/s11831-023-09922-z

Anschuetz, E. R., & Kiani, B. T. (2022). Quantum variational algorithms are swamped with traps. Nature Communications, 13(1). https://doi.org/10.1038/s41467-022-35364-5

Baccour, E., Mhaisen, N., Abdellatif, A. A., Erbad, A., Mohamed, A., Hamdi, M., & Guizani, M. (2022). Pervasive AI for IoT applications: A Survey on Resource-efficient Distributed Artificial Intelligence. https://doi.org/10.1109/COMST.2022.3200740

Badawy, M., Ramadan, N., & Hefny, H. A. (2023). Healthcare predictive analytics using machine learning and deep learning techniques: a survey. Journal of Electrical Systems and Information Technology, 10(1). https://doi.org/10.1186/s43067-023-00108-y

Batko, K., & Ślęzak, A. (2022). The use of Big Data Analytics in healthcare. Journal of Big Data, 9(1). https://doi.org/10.1186/s40537-021-00553-4

Beckey, J. L., Cerezo, M., Sone, A., & Coles, P. J. (2022). Variational quantum algorithm for estimating the quantum Fisher information. Physical Review Research, 4(1). https://doi.org/10.1103/PhysRevResearch.4.013083

Benedetti, M., Fiorentini, M., & Lubasch, M. (2021). Hardware-efficient variational quantum algorithms for time evolution. Physical Review Research, 3(3). https://doi.org/10.1103/PhysRevResearch.3.033083

Bi, H., Liu, J., & Kato, N. (2022). Deep Learning-Based Privacy Preservation and Data Analytics for IoT Enabled Healthcare. IEEE Transactions on Industrial Informatics, 18(7), 4798–4807. https://doi.org/10.1109/TII.2021.3117285

Biamonte, J. (2021). Universal variational quantum computation. Physical Review A, 103(3). https://doi.org/10.1103/PhysRevA.103.L030401

Bittel, L., & Kliesch, M. (2022). Training variational quantum algorithms is NP-hard. https://doi.org/10.1103/PhysRevLett.127.120502

Boev, A. S., Usmanov, S. R., Semenov, A. M., Ushakova, M. M., Salahov, G. V., Mastiukova, A. S., Kiktenko, E. O., & Fedorov, A. K. (2023). Quantum-inspired optimization for wavelength assignment. Frontiers in Physics, 10. https://doi.org/10.3389/fphy.2022.1092065

Bonet-Monroig, X., Wang, H., Vermetten, D., Senjean, B., Moussa, C., Bäck, T., Dunjko, V., & O’Brien, T. E. (2023). Performance comparison of optimization methods on variational quantum algorithms. https://doi.org/10.1103/PhysRevA.107.032407

Bozhedarov, A. A., Usmanov, S. R., Salakhov, G. V., Boev, A. S., Kiktenko, E. O., & Fedorov, A. K. (2024). Quantum and quantum-inspired optimization for solving the minimum bin packing problem. Journal of Physics: Conference Series, 2701(1). https://doi.org/10.1088/1742-6596/2701/1/012129

Cerezo, M., Arrasmith, A., Babbush, R., Benjamin, S. C., Endo, S., Fujii, K., McClean, J. R., Mitarai, K., Yuan, X., Cincio, L., & Coles, P. J. (2021). Variational quantum algorithms. In Nature Reviews Physics (Vol. 3, Issue 9, pp. 625–644). Springer Nature. https://doi.org/10.1038/s42254-021-00348-9

Cozzoli, N., Salvatore, F. P., Faccilongo, N., & Milone, M. (2022). How can big data analytics be used for healthcare organization management? Literary framework and future research from a systematic review. BMC Health Services Research, 22(1). https://doi.org/10.1186/s12913-022-08167-z

De Palma, G., Marvian, M., Rouzé, C., & França, D. S. (2023). Limitations of Variational Quantum Algorithms: A Quantum Optimal Transport Approach. PRX Quantum, 4(1). https://doi.org/10.1103/PRXQuantum.4.010309

Du, Y., Tu, Z., Yuan, X., & Tao, D. (2022). Efficient measure for the expressivity of variational quantum algorithms. https://doi.org/10.1103/PhysRevLett.128.080506

Fathi, H., Alsalman, H., Gumaei, A., Manhrawy, I. I. M., Hussien, A. G., & El-Kafrawy, P. (2021). An Efficient Cancer Classification Model Using Microarray and High-Dimensional Data. Computational Intelligence and Neuroscience, 2021. https://doi.org/10.1155/2021/7231126

Fontana, E., Fitzpatrick, N., Ramo, D. M., Duncan, R., & Rungger, I. (2020). Evaluating the noise resilience of variational quantum algorithms. https://doi.org/10.1103/PhysRevA.104.022403

Giron, M. C., Korpas, G., Parvaiz, W., Malik, P., & Aspman, J. (2023). Approaching Collateral Optimization for NISQ and Quantum-Inspired Computing (May 2023). IEEE Transactions on Quantum Engineering, 4. https://doi.org/10.1109/TQE.2023.3314839

Harrisha, M., Monikasree, J., Swathi, J., & Karthika, D. (2025). Smart Healthcare: Harnessing AI for Early prediction of Neurodegenerative disease. Journal of Technology Informatics and Engineering, 4(2), 214–224. https://doi.org/10.51903/jtie.v4i2.269

Hua, H., Li, Y., Wang, T., Dong, N., Li, W., & Cao, J. (2023). Edge Computing with Artificial Intelligence: A Machine Learning Perspective. ACM Computing Surveys, 55(9). https://doi.org/10.1145/3555802

Hussain, F., Nauman, M., Alghuried, A., Alhudhaif, A., & Akhtar, N. (2023). Leveraging Big Data Analytics for Enhanced Clinical Decision-Making in Healthcare. IEEE Access, 11, 127817–127836. https://doi.org/10.1109/ACCESS.2023.3332030

Huynh, L., Hong, J., Mian, A., Suzuki, H., Wu, Y., & Camtepe, S. (2023). Quantum-Inspired Machine Learning: a Survey. http://arxiv.org/abs/2308.11269

Jaksch, D., Givi, P., Daley, A. J., & Rung, T. (2022). Variational Quantum Algorithms for Computational Fluid Dynamics. https://doi.org/10.2514/1.J062426

John, A., Wen, Q., & Hua, L. (2024). Comparative Analysis of Machine Learning Algorithms for Optimizing Computational Efficiency in AI Systems. https://www.researchgate.net/publication/386452982

Kaack, L. H., Donti, P. L., Strubell, E., Kamiya, G., Creutzig, F., & Rolnick, D. (2022). Aligning artificial intelligence with climate change mitigation. Nature Climate Change, 12(6), 518–527. https://doi.org/10.1038/s41558-022-01377-7

Krishna, S., & Tulli, C. (2023). Enhancing Marketing, Sales, Innovation, and Financial Management Through Machine Learning. In INTERNATIONAL JOURNAL OF MODERN COMPUTING.

Kumar, K. E. S., S, S. B., Dalvi, R., Mittal, A., Akhtar, A., Bosco, F. D., Lineswala, R., & Chopra, A. (2024). Benchmarking of GPU-optimized Quantum-Inspired Evolutionary Optimization Algorithm using Functional Analysis. http://arxiv.org/abs/2412.08992

Letaief, K. B., Shi, Y., Lu, J., & Lu, J. (2022). Edge Artificial Intelligence for 6G: Vision, Enabling Technologies, and Applications. IEEE Journal on Selected Areas in Communications, 40(1), 5–36. https://doi.org/10.1109/JSAC.2021.3126076

Li, L., & Muwafak, B. M. (2022). Adoption of a deep learning Markov model combined with a copula function for portfolio risk measurement. Applied Mathematics and Nonlinear Sciences, 7(1), 901–916. https://doi.org/10.2478/amns.2021.2.00112

Lin, D. J., Johnson, P. M., Knoll, F., & Lui, Y. W. (2021). Artificial Intelligence for MR Image Reconstruction: An Overview for Clinicians. In Journal of Magnetic Resonance Imaging (Vol. 53, Issue 4, pp. 1015–1028). John Wiley and Sons Inc. https://doi.org/10.1002/jmri.27078

Malekloo, A., Ozer, E., AlHamaydeh, M., & Girolami, M. (2022). Machine learning and structural health monitoring overview with emerging technology and high-dimensional data source highlights. In Structural Health Monitoring (Vol. 21, Issue 4, pp. 1906–1955). SAGE Publications Ltd. https://doi.org/10.1177/14759217211036880

Mavaie, P., Holder, L., & Skinner, M. K. (2023). Hybrid deep learning approach to improve classification of low-volume high-dimensional data. BMC Bioinformatics, 24(1). https://doi.org/10.1186/s12859-023-05557-w

Mugel, S., Kuchkovsky, C., Sánchez, E., Fernández-Lorenzo, S., Luis-Hita, J., Lizaso, E., & Orús, R. (2022). Dynamic portfolio optimization with real datasets using quantum processors and quantum-inspired tensor networks. Physical Review Research, 4(1). https://doi.org/10.1103/PhysRevResearch.4.013006

Olson, K. (2023). A Comprehensive Review on Healthcare Data Analytics. Journal of Biomedical and Sustainable Healthcare Applications, 95–105. https://doi.org/10.53759/0088/jbsha202303010

Perez-Ramirez, D. F. (2024). Variational Quantum Algorithms for Combinatorial Optimization. http://arxiv.org/abs/2407.06421

Peters, E., Caldeira, J., Ho, A., Leichenauer, S., Mohseni, M., Neven, H., Spentzouris, P., Strain, D., & Perdue, G. N. (2021). Machine learning of high dimensional data on a noisy quantum processor. Npj Quantum Information, 7(1). https://doi.org/10.1038/s41534-021-00498-9

Rehman, A., Naz, S., & Razzak, I. (2020). Leveraging Big Data Analytics in Healthcare Enhancement: Trends, Challenges and Opportunities. http://arxiv.org/abs/2004.09010

Saha, S., Gan, Z., Cheng, L., Gao, J., Kafka, O. L., Xie, X., Li, H., Tajdari, M., Kim, H. A., & Liu, W. K. (2020). Hierarchical Deep Learning Neural Network (HiDeNN): an Artificial Intelligence (AI) Framework for Computational Science and Engineering. https://www.elsevier.com/open-access/userlicense/1.0/

Shen, J., Shi, J., Luo, J., Zhai, H., Liu, X., Wu, Z., Yan, C., & Luo, H. (2022). Deep learning approach for cancer subtype classification using high-dimensional gene expression data. BMC Bioinformatics, 23(1). https://doi.org/10.1186/s12859-022-04980-9

Shohel Rana, M., Shuford, J., & Author, C. (2024). AI in Healthcare: Transforming Patient Care through Predictive Analytics and Decision Support Systems. https://ojs.boulibrary.com/index.php/JAIGS

Sholekhah, D. Z., & Noviar, D. (2025). Integrative Deep Learning Architecture for High-Accuracy Medical Image Segmentation: Combining U-Net, ResNet, and Transformers. Journal of Technology Informatics and Engineering, 4(1), 115–134. https://doi.org/10.51903/jtie.v4i1.288

Stein, S., Wiebe, N., Ding, Y., Bo, P., Kowalski, K., Baker, N., Ang, J., & Li, A. (2022). EQC: Ensembled Qantum Computing for Variational Qantum Algorithms. Proceedings - International Symposium on Computer Architecture, 59–71. https://doi.org/10.1145/3470496.3527434

Tran, C., Tran, Q.-B., Son, H. T., & Dinh, T. N. (2025). Scalable Quantum-Inspired Optimization Through Dynamic Qubit Compression. www.aaai.org

Waltersmann, L., Kiemel, S., Stuhlsatz, J., Sauer, A., & Miehe, R. (2021). Artificial intelligence applications for increasing resource efficiency in manufacturing companies—A comprehensive review. In Sustainability (Switzerland) (Vol. 13, Issue 12). MDPI AG. https://doi.org/10.3390/su13126689

Wang, C., & Banko, M. (2021). Practical Transformer-based Multilingual Text Classification. https://cloud.google.com/translate

Wang, S., Fontana, E., Cerezo, M., Sharma, K., Sone, A., Cincio, L., & Coles, P. J. (2021). Noise-induced barren plateaus in variational quantum algorithms. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-27045-6

Xu, C., Yang, M., Li, C., Shen, Y., Ao, X., & Xu, R. (2021). Imagine, Reason and Write: Visual Storytelling with Graph Knowledge and Relational Reasoning. www.aaai.org

Downloads

Published

2025-12-20

How to Cite

Quantum-Inspired Optimization for High-Dimensional Data Classification in Healthcare Analytics. (2025). Journal of Technology Informatics and Engineering, 4(3), 417-435. https://doi.org/10.51903/jtie.v4i3.451